Roger Grout, 34, of New Carlisle, was ejected from his vehicle and taken to Soin Medical Center with life-threatening injuries, according to the Ohio State Highway Patrol.
CareFlight was called initially, but an ambulance transported Grout to a hospital for treatment instead, officials said.
Grout was driving a 2004 GMC Envoy east on I-70 when he lost control and hit a 2021 Chevrolet Silverado driven by Benjamin Le Clerc, 30, of of East Millinocket, Maine.
Le Clerc swerved to avoid the Envoy and hit a 2015 Ford Edge driven by Sahajkumar Patel 35, of Columbus.
Grout drove off the left side of the highway, hitting the median and going into westbound lanes of I-70. The Envoy reportedly rolled over multiple times before coming to a stop on its side in the westbound lanes.
Grout was traveling at a high rate of speed at the time of the crash, according to OSHP, but further details were not released. He was not wearing a seat belt.
Le Clerc and Patel were not injured.
Troopers are continuing to investigate the crash. Alcohol may be a factor.
This marked the second time Sunday that a section of I-70 westbound was shut down in Clark County. The earlier crash happened in the construction zone near U.S. Route 68 and shut down the interstate for nearly three hours.