Benintendi advanced on a wild pitch before Andrew Vaughn dumped an RBI single into left.
Cantillo has 10 strikeouts in his fifth career start and sixth major league appearance overall. The 24-year-old has thrown 99 pitches, 65 for strikes.
Cantillo, recalled from Triple-A Columbus earlier in the day, is looking for his first major league win. He stepped into the rotation after Alex Cobb was scratched Saturday because of a blister on his right middle finger.
Cleveland had a 5-1 lead.
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AP MLB: https://apnews.com/hub/mlb
Credit: AP
Credit: AP